Synthesis of a novel anticancer prodrug designed to target telomerase sequence
Open Access
- 1 November 2002
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Symposium Series
- Vol. 2 (1) , 277-278
- https://doi.org/10.1093/nass/2.1.277
Abstract
A curcumin conjugate viz. 1,7-bis (4- O-glycinoyl- 3-methoxyphenyl)-l,6-heptadiene-3, 5, dione (I) was synthesised and after attachment of linker (- CH2- CH2-OH) phosphitylated. This unit was attached to the deoxy- 11 mer, 5′-GTT AGG GTT AG-3′, a complementary sequence of telomerase RNA template. Its hybridisation with the telomerase RNA sequence, 5′-CUA ACC CUA AC-3′ has been studied employing Tm.Keywords
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