Failure to induce tolerance to mechlorethamine hydrochloride

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Abstract
Induction of specific immunologic tolerance to mechlorethamine hydrochloride (HN2), was investigated using a tolerogenic schedule that was reported to be effective. Mechlorethamine hydrochloride, 200 .mu.g, i.v., was given weekly for 5 wk before beginning topical therapy with it. In the test group, 5 of 13 patients (11 with mycosis fungoides and 2 with psoriasis) became contact sensitized to mechlorethamine. In another patient, what was probably a contact urticarial reaction developed. In the control group, 5 of 13 patients (12 with mycosis fungoides, 1 with parapsoriasis) became contact sensitized to mechlorethamine. Of the patients in both groups, 38% became contact sensitized to mechlorethamine. This tolerogenic schedule was not effective in inducing specific tolerance to mechlorethamine.

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