Stereospecific Synthesis of S,S-Statine and its Congeners
- 1 August 1989
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 19 (13-14) , 2573-2583
- https://doi.org/10.1080/00397918908052658
Abstract
Statine (STA, 8) and its cyclohexyl analog (ACHPA, 9) are obtained by a stereospecific synthesis via tetramic acid chemistry. Amides of STA and ACHPA, useful for the synthesis of antihyperten-sive renin inhibitors, are prepared directly from the intermediate activated lactams 7 by nucleophilic ring opening with amines.Keywords
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