INFLUENCE OF A NEW ANTIULCER AGENT, AMMONIUM 7-OXOBICYCLO (2, 2, 1) HEPT-5-ENE-3-CARBAMOYL-2-CARBOXYLATE (KF-392) ON GASTRIC LESIONS AND GASTRIC MUCOSAL BARRIER IN RATS

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Abstract
Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. KF-392 given orally at 1.0-5.0 mg/kg had a marked suppression on the development of Shay ulcer and the aspirin-, stress- and reserpine-induced gastric lesions. The effect of KF-392 on the gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition on Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa.