Is ECT Imaging with Tc(V)-99m Dimercaptosuccinic Acid Useful to Detect Lung Metastases of Osteosarcoma?
- 1 January 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Clinical Nuclear Medicine
- Vol. 10 (1) , 13-15
- https://doi.org/10.1097/00003072-198501000-00005
Abstract
ECT imaging, using Tc(V)-99m dimercaptosuccinic acid [Tc(V)-DMS] was performed in two patients with lung metastasis of osteosarcoma, and the results were compared with those of CT scan. Clear accumulation of Tc(V)-DMS was recognized in all cases in the same area that CT scans demonstrated. Tc(V)-DMS was labeled under optimal pH 8, had very low SnCl2 concentrations, an equilibrium between a stable form and a dissociated form of anion TcO43− structurally similar to PO43−, and was postulated for tumor uptake. Considering this proposed mechanism for Tc(V)-DMS uptake by tumor cells, ECT imaging using this tracer could be of use in the early detection of lung metastasis of osteosarcoma.This publication has 2 references indexed in Scilit:
- LOCALIZATION OF TC-99M MDP IN EPIPHYSEAL GROWTH PLATES OF RATS1981
- Bone Scintiscanning UpdatedAnnals of Internal Medicine, 1976