Renal Handling of Beta-2-Microglobulin in Renal Disorders; with Special Reference to Hepatorenal Syndrome

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Abstract
A study of serum β2-microglobulin and urinary β2-microglobulin in patients with liver and/or kidney disease was done to determine if such information is of diagnostic help. Serum concentrations and β2M/Cr clearance ratios are higher in patients with primary tubular disorders than in those with glomerular diseases, a finding unaltered by hepatic disease. These data suggest either an increased production or decreased tubular degradation of β2M, independent of the glomerular filtration rate (GFR), in primary tubular disorders. The marked increase in urinary β2-microglobulin that followed insertion of the peritoneal-jugular shunt is evidence that this procedure resulted in improvement of the GFR, in previously underperfused nephrons.

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