Electron Microscopic and Bioassay Studies on a Murine Leukemia Virus (Rauscher): Preliminary Report

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Abstract
A technique of negative staining has been used for the study of virus particles associated with a virus-induced leukemia in mice. Up to 80 percent of particles recovered from resuspended pellets of ultracentrifuged leukemic mouse plasma showed tail-like projections extending from the “head.” The tail-like structures varied in length up to 0.5 µ and were attached to heads of approximately 120 mµ in diameter. The heads of the particles frequently were angular, with a hexagonal shape predominating. The leukemogenic po tency was highest in those fractions of plasma in which particles were observed.

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