INCREASED OSMOTIC FRAGILITY OF ERYTHROCYTES IN CHRONICALLY JAUNDICED RATS AFTER PHOTOTHERAPY

Publisher Website
Google Scholar
Abstract
Littermate homozygous (jj) and heterozygous (Jj) Gunn rats were irradiated with blue fluorescent light for 18 h continuously. The incident irradiance was 1.5 mW/cm2 in the 420-480 nm band pass. The influence of the irradiance on circulating erythrocytes was studied by testing their osmotic fragility before and after the irradiance. The non-jaundiced Jj animals exhibited no increase in osmotic fragility of their erythrocytes. The osmotic fragility of the erythrocytes from jaundiced jj animals was the same as the Jj animals prior to irradiance. The fragility of erythrocytes from the jj animals was significantly increased after 18 h of irradiance. The photodynamic action of bilirubin may apparently be present in vivo.