Effect of intermittent altitude hypoxia on the myocardium and lesser circulation in the rat
- 1 November 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 7 (6) , 798-808
- https://doi.org/10.1093/cvr/7.6.798
Abstract
The effect of intermittent altitude hypoxia on the myocardium and lesser circulation was investigated in 58 rats. The altitude hypoxia was produced with a low pressure chamber (7,000 m, five days a week, four hours daily). This type of intermittent altitude hypoxia led to right ventricular hypertrophy in all animals after 24 exposures. A chronic pulmonary hypertension of a moderate degree was found even after intermittent altitude hypoxia (75 exposures). In this study, histological changes (focal necroses in both left and right ventricle) were observed.Keywords
This publication has 0 references indexed in Scilit: