What have we learnt from mouse models of NPM-ALK-induced lymphomagenesis?
Open Access
- 19 May 2005
- journal article
- review article
- Published by Springer Nature in Leukemia
- Vol. 19 (7) , 1128-1134
- https://doi.org/10.1038/sj.leu.2403797
Abstract
The nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is generated as a t(2;5) chromosomal breakpoint product, typically in CD30+ anaplastic large cell lymphomas. Activation of the NPM-ALK tyrosine kinase by NPM dimerisation causes autophosphorylation at multiple tyrosine residues and the consequent recruitment of a ‘signalosome’ that couples the fusion protein to pathways regulating mitogenesis and apoptosis. This review focuses on recent advances in our understanding of the transforming signals induced by this fusion protein in mouse models.Keywords
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