Carbon–carbon bond cleavage by cytochrome P450BioI(CYP107H1)
- 17 November 2003
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 1,p. 86-87
- https://doi.org/10.1039/b311652b
Abstract
Cytochrome P450BioI (CYP107H1) is believed to supply pimelic acid equivalents for biotin biosynthesis in Bacillus subtilis: we report here that the mechanistic pathway adopted by this multifunctional P450 for the in-chain cleavage of fatty acids is via consecutive formation of alcohol and threo-diol intermediates, with the likely absolute configuration of the intermediates also reported.Keywords
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