Effects of Vitamin D Supplementation on Calcium Balance and Bone Growth in Young Rats Fed Normal or Low Calcium Diet

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Abstract
Objective: We examined the effect of vitamin D supplementation on bone growth in young rats fed a normal or low calcium diet. Methods: Fifty female Sprague-Dawley rats, 6 weeks of age, were randomized by stratified weight method into five groups with 10 rats in each group: baseline control, 0.5% (normal) or 0.1% (low) calcium diet, and 0.5 or 0.1% calcium diet + vitamin D (25 µg/100 g, food intake). Duration of the experiment was 10 weeks. Results: Vitamin D supplementation stimulated intestinal calcium absorption and increased urinary calcium excretion in rats fed a low or normal calcium diet. Vitamin D supplementation prevented the reduction in periosteal bone gain but enhanced enlargement of the marrow cavity and reduced the maturation-related cancellous bone gain in rats fed a low calcium diet, and increased the maturation-related cancellous and cortical bone gains in rats fed a normal calcium diet. Conclusion: This study shows the differential effects of vitamin D supplementation on born growth in young rats fed a normal or low calcium diet.

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