A Novel Synthetic Route toN 6-Methyl-L-Iysine andN 5-Methyl-L-ornithine viaN 3-Protected (S)-3-Aminolactams
- 1 January 1991
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1991 (05) , 417-419
- https://doi.org/10.1055/s-1991-26482
Abstract
(S)-3-Phthalimido- or (S)-3-tritylaminolactams, prepared from L-lysine and L-ornithine in two or three steps, are easily methylated at the endocyclic nitrogen atom by iodomethane/silver(I) oxide in dimethylformamide. Acid hydrolysis of the N-methylated lactams thus obtained affords N6-methyl-L-lysine and N5-methyl-L-ornithine hydrochlorides in high yield.Keywords
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