Simian virus 40 large T-antigen-dependent DNA replication is activated by protein phosphatase 2A in vitro
- 1 May 1990
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 64 (5) , 2380-2383
- https://doi.org/10.1128/jvi.64.5.2380-2383.1990
Abstract
The simian virus 40 large T antigen (T) is a multifunctional phosphoprotein. We found that T-dependent simian virus 40 DNA replication is substantially inhibited by okadaic acid. This result suggests that DNA replication is activated by dephosphorylation in vitro. We show here that the target activated by dephosphorylation, which stimulates DNA replication, is T and the phosphatase involved is protein phosphatase 2A.This publication has 31 references indexed in Scilit:
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