Effects of Bicarbonate‐Containing versus Lactate‐Containing Peritoneal Dialysis Solutions on Superoxide Production by Human Neutrophils
- 1 December 1989
- journal article
- research article
- Published by Wiley in Artificial Organs
- Vol. 13 (6) , 495-497
- https://doi.org/10.1111/j.1525-1594.1989.tb01568.x
Abstract
Human neutrophils were isolated from healthy volunteers and exposed to either bicarbonate-containing (pH 7.4) or lactate-containing (pH 5.2) peritoneal dialysis solution in vitro. Superoxide production by neutrophils was measured by a method based on the superoxide dismutase-inhibitable reduction of ferricytochrome c. Bicarbonate-containing Peritoneal dialysis solution was found to be superior to the lactate-containing one in facilitating the production of superoxide anion by human neutrophils.Keywords
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