Effects of Paracetamol on Chromosomes of Mouse Bone Marrow
Open Access
- 1 January 1984
- journal article
- research article
- Published by Firenze University Press in Caryologia
- Vol. 37 (1-2) , 127-132
- https://doi.org/10.1080/00087114.1984.10797691
Abstract
Cytogenetic effects of an analgesic antipyretic agent Paracetamol were investigated on in vivo bone marrow cells of Swiss albino male mice. The mice were orally administered with 0.625, 1.25 and 2.5 mg of Paracetamol. Chromosomal pictures were prepared 24, 48 and 72 h after the administration of the drug. Chromosomal anomalies such as gaps, breaks, fragments and polyploid nuclei were observed. Structural aberrations were of chromatid type. Frequencies of these anomalies suggest that Paracetamol possess a very weak clastogenic and extremely poor c-mitotic influence in single and cumulative dose series. Cumulative doses appears to be more effective.Keywords
This publication has 12 references indexed in Scilit:
- Cytogenetic Effects of Metamizole onin VivoBone Marrow Cells of MiceCaryologia, 1983
- Mutagenicity test systems for the detection of chromosome aberrations in vivoArchives of Toxicology, 1980
- Analysis of chromosome aberrations and sister-chromatid exchanges in human lymphocytes exposed in vitro to hydergine®Mutation Research/Genetic Toxicology, 1979
- Occupational and environmental risks in and around a smelter in northern SwedenHereditas, 1978
- Cytogenetic effects of myleran in vivo on bone-marrow cells from male miceMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
- Chromosomal abnormalities in lymphocytes from monkeys poisoned with leadMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
- Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagen testsMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- Chromosome damage induced by chemicalsChemico-Biological Interactions, 1973
- Cytogenic Effects of hycanthone in the ratMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1973
- In vivo cytogenetic effects of trimethylphosphate and of tepa on bone marrow cells of male ratsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1971