Convenient Access to Polysubstituted 1-Indanones by Sc(OTf)3-Catalyzed Intramolecular Friedel−Crafts Acylation of Benzyl Meldrum's Acid Derivatives
- 23 October 2003
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (24) , 4653-4656
- https://doi.org/10.1021/ol035817m
Abstract
The intramolecular Friedel−Crafts acylation of benzyl Meldrum's acids is catalyzed by Sc(OTf)3 under mild reaction conditions. Several polysubstituted 1-indanones have been prepared.Keywords
This publication has 10 references indexed in Scilit:
- Palladium-Catalyzed Carbonylative Cyclization of Unsaturated Aryl Iodides and Dienyl Triflates, Iodides, and Bromides to Indanones and 2-CyclopentenonesJournal of the American Chemical Society, 2003
- π-Nucleophilicity in Carbon−Carbon Bond-Forming ReactionsAccounts of Chemical Research, 2002
- EFFICIENT SYNTHESIS OF THE 5-HT 2C RECEPTOR AGONIST, ORG 37684Synthetic Communications, 2001
- Friedel-Crafts Reactions Catalyzed by Rare Earth Metal TrifluoromethanesulfonatesBulletin of the Chemical Society of Japan, 2000
- Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine Hydrochloride and Related CompoundsJournal of Medicinal Chemistry, 1995
- Conjugate Addition of Grignard Reagents to Isopropylidene AlkylidenemalonatesSynthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 1982
- Conjugate Addition of Grignard Reagents to Substituted Isopropylidene MethylenemalonatesSynthetic Communications, 1980
- Meldrum's acidChemical Society Reviews, 1978
- Oxygenation of aromatic compounds with diisopropyl peroxydicarbonate-cupric chlorideThe Journal of Organic Chemistry, 1969
- CONDENSATION PRODUCTS OF ETHYL ACETO-ACETATE. I. A NEW COMPOUND OF GLYOXAL AND ETHYL ACETO-ACETATE, FORMYLMETHYLENE-BIS-ACETO-ACETIC ESTERJournal of the American Chemical Society, 1925