Regeneration of peripheral blood cells following allogeneic bone marrow transplantation for severe aplastic anaemia

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Abstract
The pattern of regeneration of peripheral blood cells was studied following ABO compatible bone marrow transplantation for severe aplastic anemia. Patients (18) were treated with cyclosporin A [CyA] and 6 with methotrexate for postgraft immunosuppression. The number of days taken for the neutrophil count to reach 0.5 .times. 109/l, the lymphocyte count to reach 1.0 .times. 109/l, the platelet count to reach 100 .times. 109/l and the reticulocytes to reach 1% was shorter in the CyA treated patients. This finding was significant for all types of cells except the platelets (neutrophils, P < 0.001; lymphocytes, P < 0.02; platelets, P < 0.05; reticulocytes, P < 0.001). The more rapid regeneration of peripheral blood cells in patients treated with CyA has contributed to reducing the length of time patients are dependent on blood product support in the posttransplant period.