In Vitro Suppression of Herpesvirus saimiri Replication by Phosphonoacetic Acid

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Abstract
Replication of Herpesvirus saimiri [HVS] was inhibited by 60 .mu.g/ml of phosphonoacetic acid (PAA) in owl monkey kidney cell cultures (OMK). OMK cells were not adversely affected by PAA. Concentrations over 1 mg/ml of PAA proved toxic to OMK cells. Pretreatment of virus or cells prior to infection had no inhibitory effect on HVS. The continued presence of PAA was required to suppress HVS replication. Removal of the drug from infected cell cultures even after 63 days resulted in the appearance of cytopathogenic effect. PAA had a greater degree of inhibition on HVS than Herpes hominis type 1.