The turnover rate of serum glycerides in the lipoproteins of fasting obese women during weight loss

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Abstract
Six obese women were housed in a metabolic facility for 2 months. During the first 15 days, the women were fed a liquid/stabilization diet, and energy intakes were adjusted for each subject to permit maintenance of an essentially constant weight. During the next 12 days, the women maintained a constant weight on these diets. During this period, glyceride turnover was determined in both the very low density (VLDL) and the low density (LDL) lipoproteins by means of the radioglycerol labeling technique. Then the energy levels of the liquid diets were adjusted so that each woman received only 50% of the kilocalories necessary to maintain weight for 12 days, and then 25% of weight maintenance kilocalories for 24 days. During the last week of acute weight loss, glyceride turnover rates were again determined. The fasting serum glyceride turnover rate for the weight-stabilized obese women was higher than that reported for normal-weight women. The maximum capacity for removal of endogenous glyceride from the serum into the adipose tissue was also higher. There was not a significant change in glyceride turnover rate during the period of acute weight loss. There was considerable individual variation. Most of the subjects showed a type 4 hyperlipoproteinemia during the weight-stabilization period. This abnormal hipoprotein pattern remained during acute weight loss despite a fall in serum glyceride concentration in all subjects.