Succinate thiokinase from Thermus aquaticus and Halobacterium salinarium

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Abstract
Both citrate synthase and succinate thiokinase occur in either a ‘large’ or ‘small’ form. The ‘large’ forms of these two enzymes have been found only in Gram‐negative bacteria, whereas Gram‐positive bacteria and eukaryotes contain the ‘small’ forms of the two. Hitherto, naturally‐occurring organisms have only been found to contain either both ‘large’ or both ‘small’ forms. The bacteria Thermus aquaticus and Halobacterium salinarium produce ‘small’ citrate synthases. In the case of the Gram‐negative organism Thermus aquaticus, this constitutes a clear exception to the general pattern. This work shows that both these bacteria contain ‘large’ succinate thiokinases, thus indicating that organisms do exist which contain mixed types of these two critic acid cycle enzymes.

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