ANTICONVULSANT INDUCED INCREASE IN 25-HYDROXY-VITAMIN D3-lα-HYDROXYLASE
- 1 December 1977
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 101 (6) , 1898-1901
- https://doi.org/10.1210/endo-101-6-1898
Abstract
Osteomalacia is associated with long-term anticonvulsant therapy [in humans]. Anticonvulsants modify the hepatic metabolism of vitamin D3 and decrease serum 25-hydroxyvitamin D3 (25-OH-D3] levels. Diphenylhydantoin (DPH) and phenobarbitone (PB) enhance the activity of kidney 25-hydroxy-vitamin D3-1.alpha.-hydroxylase (1-hydroxylase) in the chicken. Anticonvulsant osteomalacia may not be due to a lack of the active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).This publication has 0 references indexed in Scilit: