Interference between Neurotropic and Other Unrelated Viruses

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Abstract
Summary: The viruses of influenza A and B interfere with the growth and lethal action of western equine encephalomyelitis virus (Lederle strain) in the brains of mice. Influenza strains interfere, to a lesser extent, with mortality caused by eastern equine encephalomyelitis virus, St. Louis encephalitis virus, Bwamba virus, and the Rockefeller Institute strain of western equine encephalomyelitis virus. The interference is not produced if the influenza virus is given by the intraperitoneal route or if it is neutralized by immune serum; nor is it produced by several toxic agents having convulsive effect. Interference between influenza A virus (PR8 strain) and western equine encephalomyelitis (Lederle strain) could not be demonstrated in the allantoic cavity of the embryonated hen's egg. Influenza A virus inactivated by irradiation with ultraviolet light retains part of its interfering activity for western equine encephalomyelitis virus. The viruses of mumps and Newcastle disease have also the property of interfering with the growth of western equine encephalomyelitis virus (Lederle strain) in the brains of mice.

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