Inability of UV-Irradiated Lymphocytes to Stimulate Allogeneic Cells in Mixed Lymphocyte Culture

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Abstract
Cells exposed to UV light are not able to induce DNA synthesis in allogeneic cells. HL-A typing before and after irradiation gives identical results. It is suggested that active cell metabolism and not only disparity of cell surface antigens is necessary to provoke the mixed leucocyte culture reaction.