SELECTION FOR THE AFFINITY TO LUNG-TISSUE IN CELL-POPULATIONS OF EXPERIMENTAL-TUMORS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 22  (2) , 198-204
Abstract
Cell populations of 8 experimental tumors (murine and rat rhabdomyosarcomas induced with 20-methylcholantrene, transplantable murine rhabdomyosarcoma A-7 and transplantable rat lymphosarcoma) were selected for the affinity of their cells to lung tissue. The level of the affinity was measured as the number of lung nodules per 100,000 tumor cells injected i.v. A 3- to 4-fold selection appeared to be non-effective, whereas 10-fold or more prolonged selections resulted in a gradual enhancement of the affinity of tumor cells to lung tissue. Transplantable murine and rat rhabdomyosarcomas were obtained with an increased capacity of their cells for yielding lung nodules. The affinity of rat rhabdomyosarcoma was 200-300 times higher after 40 steps of selection compared to the initial tumor affinity. With the rhabdomyosarcoma of CC57W mice, the affinity increased by 5 times after 20 steps of selection. The capacity of cells to persist in lung tissue and yield lung nodules apparently is a quantitative character with a rather low heritability. In cell populations of tumors examined, there were only a few genetic population variations in cell capacity for making non-random metastases.

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