Reaction of Cuprate Reagents with Pyridine in the Presence of Chloroformate. A Novel Synthesis of 1,4-Dihydropyridine Derivatives
- 15 October 1974
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 52 (20) , 3563-3564
- https://doi.org/10.1139/v74-532
Abstract
Reaction, under appropriate conditions, of lithium dialkyl- or diarylcuprates with pyridine in the presence of methyl chloroformate afforded, in good yields, 1-carbomethoxy-4-alkyl (or aryl)-1,4-dihydropyridines. Also formed, in limited but varying amounts (∼2–11%), were the corresponding 1,2-dihydropyridine derivatives.Keywords
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