Synthesis and preliminary evaluation of a molecularly imprinted polymer selective for artificial phenolic estrogenic compounds
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Analytical Communications
- Vol. 36 (3) , 105-107
- https://doi.org/10.1039/a900197b
Abstract
A molecularly imprinted polymer has been prepared using a hexestrol template. The polymer was synthesised using diethylaminoethyl methacrylate (DAEM) as functional monomer and trimethylolpropane trimethacrylate as cross-linking monomer via a photoinitiated addition polymerisation. An equivalent blank polymer was also synthesised in the absence of the template compound. After packing into a stainless steel column (150 × 4.6 mm id), retention and elution of the template and related compounds were evaluated by high-performance liquid chromatography (HPLC). The results showed that the material synthesised in the presence of hexestrol demonstrated a selectivity towards compounds containing the stilbene carbon backbone (diethylstilbestrol, dienestrol, hexestrol).Keywords
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