Evaluation of Sodium Poly- , L-glutamate as a Plasma Expander.

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Abstract
A synthetic poly-peptide, sodium poly-[alpha], L-glutamate (SPG), was evaluated as a plasma expander by comparing it with dextran in both normovolemic and hypovolemic dogs. SPG at a concentration of 3% was equivalent to 6% dextran as a plasma expander. Further studies with SPG proved it to be too toxic for clinical trial. Two dogs died on the 6th day after intravenous injection of 3% SPG at 40 ml/kg. It was observed to impair cardiac output in the dog, and to cause agglutination and an increase in sedimentation rate of both human and dog erythrocytes. A con-siderable part of the injected dose remained in the blood at 5 hours after injection and no evidence of further elimination over the next 3 days was observed.

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