Role of Caco-2 Cell Monolayers in Prediction of Intestinal Drug Absorption
- 3 February 2006
- journal article
- review article
- Published by Wiley in Biotechnology Progress
- Vol. 22 (1) , 186-198
- https://doi.org/10.1021/bp050208u
Abstract
The usefulness of Caco‐2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review. The role of Caco‐2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.Keywords
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