Asymmetric induction in the Michael reaction by means of chiral phase-transfer catalysts derived from cinchona and ephedra alkaloids
- 1 January 1981
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 547-552
- https://doi.org/10.1039/p19810000547
Abstract
Asymmetric induction in the Michael reaction has been achieved using alkaloidonium salts in a two-phase system with optical yields of up to 36 and 26% in the addition to αβ-unsaturated ketones of thiols and nitroalkanes respectively. The presence of a hydroxy-group β to the 'onium function is essential to achieve substantial asymmetric syntheses.Keywords
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