Increased Synthesis of Lactate Dehydrogenase "H" Subunit by a Malignant Tumor
- 1 November 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 20 (11) , 1466-1469
- https://doi.org/10.1093/clinchem/20.11.1466
Abstract
In a patient with a rapidly growing malignant teratoma in the anterior mediastinum, the only biochemical abnormality detected at first was an abnormally high serum lactate dehydrogenase (EC 1.1.1.27) activity, almost 50% of the activity being present in lactate dehydrogenase isoenzyme-1 (LD1). At the time of death, the total lactate dehydrogenase activity had increased still further, 77% of it being in the LD1 fraction. Both the tumor and its hepatic metastases were shown to have a supranormally active LD1 fraction. These patterns appear to be attributable to an increased synthesis of the "H" subunit by the tumor.Keywords
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