THE RELATIONSHIP OF CORTICOID EXCRETION TO OVARIAN HORMONES IN THE GUINEA PIG1

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Abstract
THE present investigation was undertaken to study the excretion of adrenocortical hormones in the guinea pig during its estrous cycle, and to find out whether a correlation exists between ovarian function and the quantity of the excreted corticoids. It has been shown in this laboratory that the guinea pig under certain conditions is a very sensitive and suitable animal for the study of adrenocortical function by the chemical determination of urinary corticoids (Burstein, 1951). In the guinea pig, Kolmer (1912) demonstrated that the histology of the adrenal cortex is changed during the estrous cycle, and Hunt (1940) showed that the zona fasciculata contains the greatest number of mitoses during the mid-leucocyte stage of the cycle, while the zona glomerulosa exhibits the greatest number of mitoses during the cornified cell stage. In a variety of other species histological changes of the adrenal cortex have been noted during various periods of the sexual cycle.