ENDOCRINE FUNCTION OF THE HETEROTOPIC PANCREATIC ALLOTRANSPLANT IN DOGS

Abstract
Pancreatic endocrine function was investigated in dogs after heterotopic pancreatic allotransplantation. A marked hyperinsulinemia was found in peripheral venous blood within the first 60 min postoperatively. This was associated with hypoglycemia and hypokalemia occurring within the next 2-3 h resulting eventually in death. The hypoglycemia and hypokalemia could be corrected by parenteral dextrose and K given the first 2 h postoperatively or prevented by parenteral hydrocortisone given at the time of transplantation.

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