Requirement for matching T cell and B cell subsets in secondary anti‐hapten antibody responses

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Abstract
The in vitro secondary anti‐hapten response to trinitrophenylated keyhole limpet hemocyanin (TNP‐KLH) has been investigated using B and T cells from the same or a pool of identically primed syngeneic individuals. The optimum antibody response obtained from B cells of any given animal was seen when the same individual's T cells were used as a helper cell source. This individual preference was lost if secondary challenge in culture was made with TNP on a heterologous carrier, with the helper cells obtained from suitably primed individuals or a pool thereof. These data are interpreted in terms of a network theory for the regulation of immune responses under physiological conditions.