OXYGEN AND CARBON-DIOXIDE TENSIONS IN THE CANINE KIDNEY DURING ARTERIAL-OCCLUSION AND HEMORRHAGIC HYPOTENSION

  • 1 January 1984
    • journal article
    • research article
    • Vol. 158  (1) , 27-32
Abstract
Renal cortical and medullary tissue pO2 [O2 tension] and pCO2 [CO2 tension] were measured by means of implanted Silastic tonometers during arterial occlusion and graded hemorrhage in dogs. The results of studies of tissue pO2 decay curves after interruption of renal circulation suggest that a mean critical pO2 level for O2 consumption is 1.5 mm Hg for the cortex and 13 mm Hg for the medulla. Aerobic oxidative metabolism ceased at a pO2 value of 6 mm Hg in both tissue layers. At this phase, CO2 was produced anaerobically in both tissue layers. In graded hemorrhage, the critical pO2 level for O2 consumption and the minimum pO2 value for aerobic oxidative metabolism were reached earlier in the cortex than in the medulla, which may contribute to the frequent occurrence of ischemic damage and necrosis in the renal cortex after severe hemorrhagic shock.

This publication has 1 reference indexed in Scilit: