The Acidity of Norfloxacin

1 January 1990

journal article
research article
Published by CSIRO Publishing in Australian Journal of Chemistry

Vol. 43 (2) , 301-309
https://doi.org/10.1071/ch9900301

Abstract

A 1H and 13C n.m.r. investigation of the fluoroquinolone carboxylic acid Norfloxacin (1) in D2O has allowed three pKa values to be determined, which correspond to carboxylic acid oxygen (pKaD 0.6), pyridone nitrogen (pKaD 6.9) and 'external' piperazine nitrogen (pKaD 9.25) ionization.

Keywords

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