Transamination of Aminoalkylphosphonic Acids with Alpha Ketoglutarate

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Abstract
Dialyzed homogenates prepared from Escherichia coli , Tetrahymena pyriformis , sea anemone ( Anthopleura elegantissima ), and mouse liver were tested for ability to transaminate 17 aminoalkylphosphonic acids with α-ketoglutarate. 2-Aminoethylphosphonic acid (2-AEP), which occurs naturally in Tetrahymena and anemone, was transaminated by these latter organisms more than any of the substances tested, but not by preparations from liver or E. coli . 3-Aminopropylphosphonic acid was transaminated by all preparations, but much less by Tetrahymena or anemone than was 2-AEP. 2-Amino-3-phosphonopropionic acid was transaminated by all preparations. 2-Amino-4-phosphonobutyric acid was transaminated by three of the preparations, but not by liver. Of the other 13 substances tested, the following gave positive results: DL-1,2-diaminoethylphosphonic acid with E. coli , DL-1,2-diaminoethylphosphonic and aminomethylphosphonic acids with Tetrahymena , DL-1-aminopropylphosphonic acid with anemone, and DL-1-aminoethylphosphonic and DL-1-aminobutylphosphonic acids with liver. The significance of these transaminations is discussed.