Immunosuppressive Factor (or Factors) Produced by Human Embryos in Vitro

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Abstract
To the Editor: It is known that human reproduction is associated with considerable early embryonic loss. Some reports suggest that up to 60 percent of embryos lack the potential for successful implantation.1 It has also been observed that the pregnancy rates following in vitro fertilization and embryo transfer are disappointingly low.2 The causes of this high embryonic mortality are difficult to identify, but histologic assessment of failing embryos after in vitro fertilization has shown massive diffuse mononuclear-cell infiltration suggestive of immunologic rejection.3 The mechanism by which the antigenic embryo evades immunologic rejection by the mother has been the subject of . . .