Human monoclonal IgG selection ofPlasmodium falciparumfor the expression of placental malaria-specific variant surface antigens
Open Access
- 26 May 2009
- journal article
- research article
- Published by Wiley in Parasite Immunology
- Vol. 31 (6) , 341-346
- https://doi.org/10.1111/j.1365-3024.2009.01097.x
Abstract
Pregnancy-associated Plasmodium falciparum malaria (PAM) is a major cause of morbidity and mortality in African women and their offspring. PAM is characterized by accumulation of infected erythrocytes (IEs) that adhere to chondroitin sulphate A (CSA) in the placental intervillous space. We show here that human monoclonal IgG antibodies with specificity for variant surface antigens (VSA) specifically expressed by CSA-adhering IEs (VSAPAM) can be used in vitro to select parasites from nonpregnant donors to express VSAPAM and that this selection for VSAPAM expression results in preferential transcription of var2csa. The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA.Keywords
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