Nephrotoxicity of contrast media assessed by occlusion arteriography.

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Abstract
An experimental model [dog] for the study of nephrotoxicity induced by contrast media is described. It was based on a standardized injection, combined with occlusion of the renal artery so as to expose the kidney to a high concentration of contrast medium for 10 min. Iopamidol, ioxaglate and both isosmolar and hyperosmolar saline were well tolerated, but diatrizoate caused marked radiological and pathological changes. This model may be helpful in studies of the mechanisms underlying contrast medium nephrotoxicity [in humans], and in evaluating differences in toxicity between contrast agents.