Effect of nitrofurantoin on meiosis of the male mouse
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 39 (3) , 345-351
- https://doi.org/10.1007/bf00295430
Abstract
The effects of nitrofurantoin [N-(5-nitro-2-furfurylidine)-1-amino-hydantoin] on chromosomes of primary and secondary spermatocytes of mice were studied. No mutagenic activity was detectable after application of either 8 mg/kg or 40 mg/kg nitrofurantoin. An increase in the univalent rates and a decrease in the chiasma frequencies was observed in treated animals. The probable origins of these effects are discussed.This publication has 27 references indexed in Scilit:
- Mutagenic activity of carcinogenic and noncarcinogenic nitrofurans and of urine of rats fed these compoundsChemico-Biological Interactions, 1976
- Nondisjunction in aging female miceCytogenetic and Genome Research, 1976
- Chiasmata, meiotic univalents, and age in relation to aneuploid imbalance in miceCytogenetic and Genome Research, 1976
- On the mutagenicity of nitrofuransMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
- X-Y chromosome dissociation and sterility in the mouseCytogenetic and Genome Research, 1973
- Chiasma and univalent frequencies in aging female miceCytogenetic and Genome Research, 1973
- Studies of meiosis in vitroDevelopmental Biology, 1967
- A Reciprocal Translocation in the Mouse Between the X Chromosome and a Short AutosomeCytogenetic and Genome Research, 1964
- Duration of Spermatogenesis in the MouseNature, 1957
- Cytotoxic effects of a nitrofuran on the rat testisCancer, 1950