Unaltered [3H]GBR-12935 binding after chronic treatment with dopamine active drugs
- 1 November 1990
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 102 (3) , 291-294
- https://doi.org/10.1007/bf02244092
Abstract
Rats were injected intraperitoneally with haloperidol 0.5 mg/kg, raclopride 1 mg/kg, bromocriptine 2.5 mg/kg,d-amphetamine 2.5 mg/kg, or cocaine 10 mg/kg twice daily for 21 days. The animals were sacrificed 72 h after last injection. Control rats were injected with saline, following the same schedule. The radioligand [3H]GBR-12935 was used as a presynaptic marker for dopamine neurites. There were no significant differences in [3H]GBR-12935 binding to striatum between drug-treated rats and controls.This publication has 22 references indexed in Scilit:
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