Absorption, distribution, metabolism and excretion of N-cyclohexyl-2-benzothiazyl sulfenamide(CBS), a vulcanizing accelerator, in rats.
Open Access
- 1 January 1989
- journal article
- abstracts
- Published by Japan Radioisotope Association in RADIOISOTOPES
- Vol. 38 (5) , 255-258
- https://doi.org/10.3769/radioisotopes.38.5_255
Abstract
Absorption, distribution, metabolism and excretion were studied in rats following a single oral administration of N-cyclohexyl-2-benzothiazyl sulfenamide (CBS) at a dose of 250 mg/kg. About 65% and 24% of the dose were excreted into urine and feces, respectively, for 3 days after administration of labeled CBS (cyclohexyl-14C). Biliary excretion amounted to about 5% of the dose for 3 days. While about 92% of the dose was recovered in urine and feces at a ratio of 1:1 within 3 days when 14C-2CBS was given. No specific organ-affinity was observed in distribution study. Cyclohexylamine and 2-mercaptobenzothiazole were identified as urinary metabolites.Keywords
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