Studies on the Behavioral Pharmacology of TRH-T in Cytosine Arabinoside-Induced Ataxic Mice: A Comparison with Genetically Ataxic Mice
- 1 January 1983
- journal article
- research article
- Published by Japanese Association for Laboratory Animal Science in Experimental Animals
- Vol. 32 (1) , 13-19
- https://doi.org/10.1538/expanim1978.32.1_13
Abstract
The effects of TRH tartrate (TRH-T) on the behavior of cytosine arabinoside (Ara-C) induced ataxic mice were studied. The ataxic mice were prepared by injecting 50 mg/kg per day s.c. on the 2nd, 3rd and 4th postnatal days. Spontaneous motor activities were measured with a movement spectrum analyzer (ANIMEX-2) and the degree of ataxic gait determined by an open-field study. Cerebella from these animals were subjected to histopathologic examination at 4, 8 and 12 wk of age. Ataxic gait became improved moderately and spontaneous motor activities increased slightly following administration of TRH-T. The effects of TRH-T on ataxia and spontaneous motility in the Ara-C injected mice varied with the age, and resembled those seen in weaver mice but not those in the Rolling mouse Nagoya. The effects of TRH-T on the behavior of ataxic mice correlate with the extent of pathologic changes evoked in their cerebella.This publication has 0 references indexed in Scilit: