Nitric Oxide Modulates Oxygen Sensing by Hypoxia-inducible Factor 1-dependent Induction of Prolyl Hydroxylase 2
Open Access
- 1 January 2007
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 282 (3) , 1788-1796
- https://doi.org/10.1074/jbc.m607065200
Abstract
No abstract availableKeywords
This publication has 50 references indexed in Scilit:
- The biology of hypoxia: the role of oxygen sensing in development, normal function, and diseaseGenes & Development, 2004
- Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic SwitchScience, 2002
- A Conserved Family of Prolyl-4-Hydroxylases That Modify HIFScience, 2001
- FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activityGenes & Development, 2001
- HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 SensingScience, 2001
- Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl HydroxylationScience, 2001
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisNature, 1999
- Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathwayProceedings of the National Academy of Sciences, 1998
- Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic ConditionsJournal of Biological Chemistry, 1997
- Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.Proceedings of the National Academy of Sciences, 1995