Pneumocandins from Zalerion arboricola. I. Discovery and isolation.
- 1 January 1992
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 45 (12) , 1853-1866
- https://doi.org/10.7164/antibiotics.45.1853
Abstract
HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688, 786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671, 329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneurnocandins A0 and B0 in the hydroxylation patterns on the ornithine, homotyrosine, and proline.Keywords
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