Vasopressor Effect of Synthetic 5-Hydroxytryptamine Creatinine Sulfate in Man.

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Abstract
Intravenous injection of 0.3 ug/minute of 5-hydroxytryptamine creatinine sulfate (5-HT) caused transitory elevation of the local venous pressure; higher doses induced more marked elevation of local venous pressure and, when given in a short period of time, of arterial pressure. Elevation of systemic venous pressure was not obtained even with extremely high doses of 5-HT. Intra-arterial administration of 5-HT induced sustained elevation of the venous pressure in the homolateral vein (30 minutes or longer). Elevation of arterial pressure and generalized flushing followed injection into a patient with septal venous-arterial shunt of a dose of 5-HT unable to cause such effect in normal subjects. It is postulated that injected 5-HT is quickly removed from the circulation, perhaps by platelets or by other cellular elements retained in capillary beds and released slowly at later time. This effect may play a role in the control of venous pressure in peripheral areas.