Crystal structure of Trypanosoma cruzi glyceraldehyde‐3‐phosphate dehydrogenase complexed with an analogue of 1,3‐bisphospho‐d‐glyceric acid
Open Access
- 23 October 2003
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 270 (22) , 4574-4586
- https://doi.org/10.1046/j.1432-1033.2003.03857.x
Abstract
We report here the first crystal structure of a stable isosteric analogue of 1,3-bisphospho-d-glyceric acid (1,3-BPGA) bound to the catalytic domain of Trypanosoma cruzi glycosomal glyceraldehyde-3-p...Keywords
This publication has 47 references indexed in Scilit:
- Adenosine Analogues as Selective Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase of Trypanosomatidae via Structure-Based Drug DesignJournal of Medicinal Chemistry, 2001
- Glycolysis as a target for the design of new anti-trypanosome drugsDrug Resistance Updates, 2001
- Compartmentation protects trypanosomes from the dangerous design of glycolysisProceedings of the National Academy of Sciences, 2000
- What Controls Glycolysis in Bloodstream Form Trypanosoma brucei?Journal of Biological Chemistry, 1999
- Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenaseProceedings of the National Academy of Sciences, 1999
- Glycolysis in Bloodstream Form Trypanosoma brucei Can Be Understood in Terms of the Kinetics of the Glycolytic EnzymesJournal of Biological Chemistry, 1997
- Use of Mathematical Models for Predicting the Metabolic Effect of Large‐Scale Enzyme Activity AlterationsEuropean Journal of Biochemistry, 1995
- The cytosolic and glycosomal glyceraldehyde‐3‐phosphate dehydrogenase from Trypanosoma bruceiEuropean Journal of Biochemistry, 1991
- Aerobic glucose fermentation by Trypanosoma cruzi axenic culture amastigote-like forms during growth and differentiation to epimastigotesMolecular and Biochemical Parasitology, 1987
- Compartmentation Of Carbohydrate Metabolism In TrypanosomesAnnual Review of Microbiology, 1987