A Case of Interstitial Pneumonitis Associated with Natural α-lnterferon Therapy for Myelofibrosis
- 1 January 1997
- journal article
- case report
- Published by S. Karger AG in Acta Haematologica
- Vol. 97 (4) , 222-224
- https://doi.org/10.1159/000203687
Abstract
A 55-year-old man with myelofibrosis was treated with natural α-interferon with a good hematologic response. Initially, he had anemia, leukocytosis, thrombocytosis and hepatosplenomegaly. A bone marrow biopsy showed replacement with fibrosis with an increase in megakaryocytes. Natural α-interferon (α-IFN) was started at a dose of 3 × 106 units/day. The leukocyte and platelet counts gradually normalized, and the liver and spleen decreased in size. However, the patient complained of a dry cough and dyspnea on the 61st treatment day, when the accumulated dose of α-IFN treatment had reached 1.8 × 108 units. He subsequently developed acute respiratory failure (PaO2Keywords
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