OPTIMAL DOSE OF LIGNOCAINE FOR PREVENTING PAIN ON INJECTION OF PROPOFOL
Open Access
- 1 March 1991
- journal article
- clinical trial
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 66 (3) , 324-326
- https://doi.org/10.1093/bja/66.3.324
Abstract
The purpose of this study was to define the optimum dose of lignocaine required to reduce pain on injection of propofol. We conducted a prospective, randomized, double-blind trial on 310 patients undergoing anaesthesia. Patients were allocated to four groups according to the lignocaine dosage: group A (control), no lignocaine; group B, lignocaine 0.1 mg kg−1; group C, lignocaine 0.2mgkg−1; group D, lignocaine 0.4mg kg−1. Our results showed that a dose of lignocaine 0.1 mg kg−1 significantly reduced the incidence of pain and that there was no improvement when the dose was increased.Keywords
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